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Article

Extreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa.

PLoS genetics - 1 Feb 2014

Engelken Johannes, Carnero-Montoro Elena, Pybus Marc, Andrews Glen K, Lalueza-Fox Carles, Comas David, Sekler Israel, de la Rasilla Marco, Rosas Antonio, Stoneking Mark, Valverde Miguel A, Vicente Rubén, Bosch Elena

Abstract excerpt

Extreme differences in allele frequency between West Africans and Eurasians were observed for a leucine-to-valine substitution (Leu372Val) in the human intestinal zinc uptake transporter, ZIP4, yet no further evidence was found for a selective sweep around the ZIP4 gene (SLC39A4). By interrogating allele frequencies in more than 100 diverse human populations and resequencing Neanderthal DNA, we confirmed the...

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PMID: 24586184
DOI: 10.1371/journal.pgen.1004128
PMCID: PMC3930504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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