Article
Severe α1-antitrypsin deficiency associated with lower blood pressure and reduced risk of ischemic heart disease: a cohort study of 91,540 individuals and a meta-analysis.
Respiratory research - 9 Mar 2022
Winther Sine Voss, Ahmed Dunia, Al-Shuweli Suzan, Landt Eskild Morten, Nordestgaard Børge Grønne, Seersholm Niels, Dahl Morten
Abstract excerpt
BACKGROUND: Increased elastase activity in α1-antitrypsin deficiency may affect elasticity of the arterial walls, and thereby blood pressure and susceptibility to cardiovascular disease. We hypothesized that severe α1-antitrypsin deficiency is associated with reduced blood pressure and susceptibility to cardiovascular disease. METHODS: We genotyped 91,353 adults randomly selected from the Danish general...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.