Article
Vaccine breakthrough infections with SARS-CoV-2 Alpha mirror mutations in Delta Plus, Iota, and Omicron.
The Journal of clinical investigation - 2 May 2022
Martínez-González Brenda, Vázquez-Sirvent Lucía, Soria María E, Mínguez Pablo, Salar-Vidal Llanos, García-Crespo Carlos, Gallego Isabel, de Ávila Ana I, Llorens Carlos, Soriano Beatriz, Ramos-Ruiz Ricardo, Esteban Jaime, Fernandez-Roblas Ricardo, Gadea Ignacio, Ayuso Carmen, Ruíz-Hornillos Javier, Pérez-Jorge Concepción, Domingo Esteban, Perales Celia
Abstract excerpt
Replication of SARS-CoV-2 in the human population is defined by distributions of mutants that are present at different frequencies within the infected host and can be detected by ultra-deep sequencing techniques. In this study, we examined the SARS-CoV-2 mutant spectra of amplicons from the spike-coding (S-coding) region of 5 nasopharyngeal isolates derived from patients with vaccine breakthrough. Interestingly,...
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