Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transgene-design: a web application for the design of mammalian transgenes.

Bioinformatics (Oxford, England) - 28 Apr 2022

Mühlhausen Stefanie, Hurst Laurence D

Abstract excerpt

SUMMARY: Transgene-design is a web application to help design transgenes for use in mammalian studies. It is predicated on the recent discovery that human intronless transgenes and native retrogenes can be expressed very effectively if the GC content at exonic synonymous sites is high. In addition, as exonic splice enhancers resident in intron containing genes may have different utility in intronless genes, these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mammals
Share to Exons
Share to Introns

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Software

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 35244144
DOI: 10.1093/bioinformatics/btac139
PMCID: PMC9048660

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Transgene-design: a web application for the design of mammalian transgenes.PMID 35244144Read ↗

TransgeneR: a one-stop tool for transgene integration and rearrangement discovery using sequencing dataSemantic proximity Read ↗

A protocol for locating and counting transgenic sequences from laboratory animals using a map-then-capture (MapCap) sequencing workflow: procedure and application of resultsSemantic proximity Read ↗

Computationally defined and <i>in vitro</i> validated putative genomic safe harbour loci for transgene expression in human cellsSemantic proximity Read ↗

Analysis of the transgene insertion pattern in a transgenic mouse strain using long-read sequencing.Semantic proximity Read ↗

Binary AdEasy vector systems designed for Tet-ON or Tet-OFF regulated control of transgene expressionSemantic proximity Read ↗

Differentiating allele combinations of a transgene using multiple primer PCR.Semantic proximity Read ↗

A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice.Semantic proximity Read ↗

Chicken beta-globin 5'HS4 insulators function to reduce variability in transgenic founder mice.Semantic proximity Read ↗

Validation of novel promoter sequences derived from two endogenous ubiquitin genes in transgenic <i>Aedes aegypti</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.