Article
ANXA1 and the risk for early-onset Parkinson's disease.
Neurobiology of aging - 1 Apr 2022
Li Chunyu, Ou Ruwei, Gu Xiaojing, Hou Yanbing, Chen Yongping, Wei Qianqian, Zhang Lingyu, Lin Junyu, Liu Kuncheng, Huang Jingxuan, Chen Xueping, Song Wei, Zhao Bi, Wu Ying, Shang Huifang
Abstract excerpt
Recently, homozygous missense variants in ANXA1 were identified to cause parkinsonism by segregation analysis in a consanguineous family. However, no further replication has been conducted in a wider range of Parkinson's disease (PD) populations. To investigate the involvement of ANXA1 mutations in PD, we analyzed the rare variants in 743 Chinese early-onset PD (EOPD) patients (age at onset <50) using whole exome...
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