Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lack of association between the APEX1 Asp148Glu polymorphism and sporadic amyotrophic lateral sclerosis.

Neurobiology of aging - 1 Feb 2010

Coppedè Fabio, Lo Gerfo Annalisa, Carlesi Cecilia, Piazza Selina, Mancuso Michelangelo, Pasquali Livia, Murri Luigi, Migliore Lucia, Siciliano Gabriele

Abstract excerpt

Impairments in DNA repair enzymes have been observed in amyotrophic lateral sclerosis (ALS) tissues, particularly in the activity of the apurinic/apyrimidinic endonuclease 1 (APEX1). Moreover, it was suggested that the common APEX1 Asp148Glu polymorphism might be associated with ALS risk. To further address this question we performed the present study aimed at evaluating the contribution of the APEX1 Asp148Glu...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Amyotrophic Lateral Sclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Disease Progression

Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

Share to Mutation, Missense

Share to White People

Source

Identifiers

PMID: 18482781
DOI: 10.1016/j.neurobiolaging.2008.03.018

Genes

APEX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of association between the APEX1 Asp148Glu polymorphism and sporadic amyotrophic lateral sclerosis.PMID 18482781Read ↗

Molecular genetic analysis of the <i>APEX nuclease</i> gene in amyotrophic lateral sclerosisSemantic proximity Read ↗

Association study between XRCC1 gene polymorphisms and sporadic amyotrophic lateral sclerosis.Semantic proximity Read ↗

Association of the hOGG1 Ser326Cys polymorphism with sporadic amyotrophic lateral sclerosis.Semantic proximity Read ↗

Lack of an association between SCFD1 rs10139154 polymorphism and amyotrophic lateral sclerosis.Semantic proximity Read ↗

The -A162G polymorphism of the PON1 gene and the risk of sporadic amyotrophic lateral sclerosis.Semantic proximity Read ↗

SOD1 gene mutations in Italian patients with Sporadic Amyotrophic Lateral Sclerosis (ALS).Semantic proximity Read ↗

The IVS1 +319 t>a of SOD1 gene is not an ALS causing mutation.Semantic proximity Read ↗

Putative founder effect in the Polish, Iranian and United States populations for the L144S SOD1 mutation associated with slowly uniform phenotype of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Genetic analysis of SS18L1 in French amyotrophic lateral sclerosis.Semantic proximity Read ↗

A 50 bp deletion in the SOD1 promoter lowers enzyme expression but is not associated with ALS in Sweden.Semantic proximity Read ↗

An Italian dominant FALS Leu144Phe SOD1 mutation: genotype-phenotype correlation.Semantic proximity Read ↗

Analysis of STMN2 CA repeats in italian ALS patients shows no association.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.