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Article

Product release is rate-limiting for catalytic processing by the Dengue virus protease.

Scientific reports - 29 Nov 2016

Shannon A E, Pedroso M M, Chappell K J, Watterson D, Liebscher S, Kok W M, Fairlie D P, Schenk G, Young P R

Abstract excerpt

Dengue Virus (DENV) is the most prevalent global arbovirus, yet despite an increasing burden to health care there are currently no therapeutics available to treat infection. A potential target for antiviral drugs is the two-component viral protease NS2B-NS3pro, which is essential for viral replication. Interactions between the two components have been investigated here by probing the effect on the rate of enzyme...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27897196
DOI: 10.1038/srep37539
PMCID: PMC5126634

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