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A new hemizygous missense mutation, c.454T＞C (p.S152P), in AKAP4 gene is associated with asthenozoospermia.

Molecular reproduction and development - 1 Sept 2021

Gu Longjie, Liu Xiaming, Yang Jun, Bai Jian

Abstract excerpt

Asthenozoospermia (ASZ) is a condition characterized by reduced forward motility of spermatozoa affecting approximately 19% of infertile men. A kinase anchor protein 4 (AKAP4) is an X-linked testis-specific gene and plays a major role in sperm motility and flagella formation. However, few studies have reported its association with ASZ. Here, we sequenced for exonic mutations of human AKAP4 gene by high-fidelity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34409659
DOI: 10.1002/mrd.23529

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