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Methylation of SDC2/TFPI2 and Its Diagnostic Value in Colorectal Tumorous Lesions

22 Dec 2021

Abstract excerpt

Background: SDC2 methylation is a feasible biomarker for colorectal cancer detection. Its specificity for colorectal cancer is higher than 90%, but the sensitivity is normally lower than 90%. This study aims to improve the sensitivity of SDC2 detection through finding a high positive target from the false-negative samples of SDC2 detection based on analysis of the bowel subsite difference in methylation. Methods:...

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Share to Colorectal Cancer Screening and Detection
Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer

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PMID: 35004840
DOI: 10.3389/fmolb.2021.706754

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