Article
Concurrent impact of de novo mutations on cranial and cortical development in nonsyndromic craniosynostosis.
Journal of neurosurgery. Pediatrics - 1 Jan 2024
Kiziltug Emre, Duy Phan Q, Allington Garrett, Timberlake Andrew T, Kawaguchi Riki, Long Aaron S, Almeida Mariana N, DiLuna Michael L, Alper Seth L, Alperovich Michael, Geschwind Daniel H, Kahle Kristopher T
Abstract excerpt
OBJECTIVE: Nonsyndromic craniosynostosis (nsCS), characterized by premature cranial suture fusion, is considered a primary skull disorder in which impact on neurodevelopment, if present, results from the mechanical hindrance of brain growth. Despite surgical repair of the cranial defect, neurocognitive deficits persist in nearly half of affected children. Therefore, the authors performed a functional genomics...
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