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Article

Aurora kinase genetic polymorphisms: an association study in Down syndrome and spontaneous abortion.

Human cell - 1 May 2022

de Castro Carolina Monteiro Leite, Pereira Carolina Oliveto Bastos, Aprigio Joissy, Costa Lima Marcelo A, Ribeiro Márcia G, Amorim Márcia Rodrigues

Abstract excerpt

Aneuploidies, such as Down syndrome (DS), are the leading cause of pregnancy loss. Abnormalities in aurora kinase proteins result in genomic instability and aneuploidy, mainly in tumors. Thus, polymorphisms in Aurora kinase genes could influence the occurrence of DS and spontaneous abortion. A case-control study was conducted including 124 mothers of DS children (DSM) and 219 control mothers (CM) to investigate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 35218477
DOI: 10.1007/s13577-022-00686-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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