Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNMT3B promoter polymorphisms and maternal risk of birth of a child with Down syndrome.

Human reproduction (Oxford, England) - 1 Feb 2013

Coppedè Fabio, Bosco Paolo, Tannorella Pierpaola, Romano Carmelo, Antonucci Ivana, Stuppia Liborio, Romano Corrado, Migliore Lucia

Abstract excerpt

STUDY QUESTION: Are DNMT3B promoter polymorphisms among maternal risk factors for the birth of a child with Down syndrome (DS)? SUMMARY ANSWER: Present results suggest that combinations of functional DNMT3B promoter polymorphisms might modulate maternal risk of birth of a child with DS. WHAT IS KNOWN ALREADY: The DNMT3B gene codes for DNA methyltransferase 3b (DNMT3b), a protein required for genome-wide de novo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3B

Share to Down Syndrome

Share to Genetic Association Studies

Share to Pregnancy

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 23081874
DOI: 10.1093/humrep/des376

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNMT3B promoter polymorphisms and maternal risk of birth of a child with Down syndrome.PMID 23081874Read ↗

Maternal risk for down syndrome and polymorphisms in the promoter region of the DNMT3B gene: a case-control study.Semantic proximity Read ↗

Betaine-homocysteine methyltransferase 742G>A polymorphism and risk of down syndrome offspring in a Brazilian population.Semantic proximity Read ↗

DNMT3B rs2424913 as a Risk Factor for Congenital Heart Defects in Down Syndrome.Semantic proximity Read ↗

The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defectsSemantic proximity Read ↗

Association between MTHFR C677T and A1298C gene polymorphisms and maternal risk for Down syndrome: A protocol for systematic review and/or meta-analysis.Semantic proximity Read ↗

BHMT G742A and MTHFD1 G1958A polymorphisms and Down syndrome risk in the Brazilian population.Semantic proximity Read ↗

Association of C677T and A1298C polymorphisms of the MTHFR gene with maternal risk for Down syndrome: A meta-analysis of case-control studies.Semantic proximity Read ↗

Maternal gene polymorphisms involved in folate metabolism and the risk of having a Down syndrome offspring: a meta-analysis.Semantic proximity Read ↗

Maternal gene polymorphisms involved in folate metabolism as risk factors for Down syndrome offspring in Southern Brazil.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphisms C677T and A1298C as maternal risk factors for Down syndrome in Jordan.Semantic proximity Read ↗

Identification of a DNA methylation signature in blood cells from persons with Down SyndromeSemantic proximity Read ↗

The MTRR 66A>G polymorphism and maternal risk of birth of a child with Down syndrome in Caucasian women: a case-control study and a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.