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Insights into the roles of sperm in animal cloning

18 Feb 2020

Abstract excerpt

Somatic cell nuclear transfer (SCNT) has shown a wide application in the generation of transgenic animals, protection of endangered animals, and therapeutic cloning. However, the efficiency of SCNT remains very low due to some poorly characterized key factors. Compared with fertilized embryos, somatic donor cells lack some important components of sperm, such as sperm small noncoding RNA (sncRNA) and proteins....

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PMID: 32070430
DOI: 10.1186/s13287-020-01599-6

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