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Article

Effects of microRNA-298 on APP and BACE1 translation differ according to cell type and 3'-UTR variation.

Scientific reports - 23 Feb 2022

Wang Ruizhi, Lahiri Debomoy K

Abstract excerpt

Alzheimer's disease (AD) is marked by neurofibrillary tangles and senile plaques composed of amyloid β (Aβ) peptides. However, specific contributions of different cell types to Aβ deposition remain unknown. Non-coding microRNAs (miRNA) play important roles in AD by regulating translation of major associated proteins, such as Aβ precursor protein (APP) and β-site APP-cleaving enzyme (BACE1), two key proteins...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35197498
DOI: 10.1038/s41598-022-05164-4
PMCID: PMC8866491

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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