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Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-β

11 Jun 2010

Abstract excerpt

Normal brain development and function depends on microRNA (miRNA) networks to fine tune the balance between the transcriptome and proteome of the cell. These small non-coding RNA regulators are highly enriched in brain where they play key roles in neuronal development, plasticity and disease. In neurodegenerative disorders such as Alzheimer's disease (AD), brain miRNA profiles are altered; thus miRNA dysfunction...

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PMID: 20552018
DOI: 10.1371/journal.pone.0011070

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