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Article

MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy

28 Jan 2021

Abstract excerpt

Age-related macular degeneration (AMD) is a progressive sight-impairing disease of the elderly. The pathogenic mechanisms of AMD are not well understood although both genetic and many environmental factors have been associated with the development of AMD. One clinical hallmark of AMD is the detrimental aggregation of damaged proteins. Recently, it has been suggested that the weakening of autophagy clearance is an...

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PMID: 33516915
DOI: 10.1016/j.arr.2021.101260

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