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Article

The eigen higher criticism and eigen Berk-Jones tests for multiple trait association studies based on GWAS summary statistics.

Genetic epidemiology - 1 Mar 2022

Liu Wei, Xu Yuyang, Wang Anqi, Huang Tao, Liu Zhonghua

Abstract excerpt

In this article, we propose the eigen higher criticism and the eigen Berk-Jones testing procedures to test the association between a single genetic variant and multiple correlated traits based on summary statistics from single-trait genome-wide association studies. Since the association pattern between each genetic variant and multiple traits varies across the whole genome, we further develop an omnibus (OMNI)...

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PMID: 35192735
DOI: 10.1002/gepi.22439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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