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Article

Large changes in detected selection signatures after a selection limit in mice bred for voluntary wheel-running behavior.

PloS one - 1 Jan 2024

Hillis David A, Yadgary Liran, Weinstock George M, de Villena Fernando Pardo-Manuel, Pomp Daniel, Garland Theodore

Abstract excerpt

In various organisms, sequencing of selectively bred lines at apparent selection limits has demonstrated that genetic variation can remain at many loci, implying that evolution at the genetic level may continue even if the population mean phenotype remains constant. We compared selection signatures at generations 22 and 61 of the "High Runner" mouse experiment, which includes 4 replicate lines bred for voluntary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39088483
DOI: 10.1371/journal.pone.0306397
PMCID: PMC11293672

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