Article
Castration-resistant prostate cancer patient presenting with whole genome doubling with CDK-12 mutation.
BMC medical genomics - 19 Feb 2022
Baba Yuto, Kosaka Takeo, Kobayashi Hiroaki, Nakamura Kohei, Mikami Shuji, Nishihara Hiroshi, Nakanishi Makoto, Oya Mototsugu
Abstract excerpt
BACKGROUND: The use of whole-genome sequencing in clinical practice has revealed variable genomic characteristics across cancer types, one of which is whole-genome doubling (WGD), which describes the duplication of a complete set of chromosomes. Yet it is relatively rare in prostate cancer and no such case has ever been reported in Japanese patients. CASE PRESENTATION: A 54-year-old patient with prostatic...
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