Article

The SARS-CoV-2 host cell membrane fusion protein TMPRSS2 is a tumor suppressor and its downregulation promotes antitumor immunity and immunotherapy response in lung adenocarcinoma

2022-02-22

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>TMPRSS2, a key molecule for SARS-CoV-2 invading human host cells, has an association with cancer. However, its association with lung cancer remains unexplored. <bold>Results</bold>In five lung adenocarcinoma (LUAD) genomics datasets, we explored associations between <italic>TMPRSS2</italic> expression and immune signatures, tumor progression phenotypes, and clinic...

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Literature Corpus work: 6807249d-e9a0-5933-9790-8caccad42304
DOI: 10.21203/rs.3.rs-740479/v3

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