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Dihydroceramide- and ceramide-profiling provides insights into human cardiometabolic disease etiology

17 Feb 2022

Abstract excerpt

Metabolic alterations precede cardiometabolic disease onset. Here we present ceramide- and dihydroceramide-profiling data from a nested case-cohort (type 2 diabetes [T2D, n = 775]; cardiovascular disease [CVD, n = 551]; random subcohort [n = 1137]) in the prospective EPIC-Potsdam study. We apply the novel NetCoupler-algorithm to link a data-driven (dihydro)ceramide network to T2D and CVD risk. Controlling for...

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PMID: 35177612
DOI: 10.1038/s41467-022-28496-1

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