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Article

Cardiomyopathic mutations in essential light chain reveal mechanisms regulating the super relaxed state of myosin.

The Journal of general physiology - 5 Jul 2021

Sitbon Yoel H, Diaz Francisca, Kazmierczak Katarzyna, Liang Jingsheng, Wangpaichitr Medhi, Szczesna-Cordary Danuta

Abstract excerpt

In this study, we assessed the super relaxed (SRX) state of myosin and sarcomeric protein phosphorylation in two pathological models of cardiomyopathy and in a near-physiological model of cardiac hypertrophy. The cardiomyopathy models differ in disease progression and severity and express the hypertrophic (HCM-A57G) or restrictive (RCM-E143K) mutations in the human ventricular myosin essential light chain (ELC),...

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Identifiers

PMID: 34014247
DOI: 10.1085/jgp.202012801
PMCID: PMC8142263

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