Article
Integrin-β4 regulates the dynamic changes of phenotypic characteristics in association with epithelial-mesenchymal transition (EMT) and RhoA activity in airway epithelial cells during injury and repair.
International journal of biological sciences - 1 Jan 2022
Tan Mei-Ling, Huang Wen-Jie, Wang Yue, Liu Lei, Pan Yan, Li Jing-Jing, Zhang Jiang, Ouyang Mingxing, Qu Xiang-Ping, Liu Hui-Jun, Liu Chi, Zeng Dan, Qin Xiao-Qun, Deng Linhong, Xiang Yang
Abstract excerpt
Background: In airway disease such as asthma a hyperactive cellular event of epithelial-mesenchymal transition (EMT) is considered as the mechanism of pathological airway tissue remodeling after injury to the airway epithelium. And the initiation of EMT in the airways depends on the epithelial disruption involving dissolution and/or destabilization of the adhesive structures between the cells and ECM. Previously,...
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