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Article

Serum Creatinine Protects Against Amyotrophic Lateral Sclerosis: a Mendelian Randomization Study.

Molecular neurobiology - 1 Jun 2021

Wang Mengmeng, Liu Dandan, Zhang Zhizhong, Xie Wei, Cao Liping, Zhu Linfeng, Liu Meng, Sheng Shiying, Lian Xuegan

Abstract excerpt

Association between serum creatinine (sCr) and amyotrophic lateral sclerosis (ALS) has been reported in previous observational studies, but results are at risk of confounding bias and reverse causation. Therefore, whether such association is casual remains unclear. Herein, we performed a two-sample Mendelian randomization study to evaluate the causal relationship between sCr and ALS in both European and East...

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PMID: 33555548
DOI: 10.1007/s12035-021-02309-w

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