Obstructive sleep apnea and atrial fibrillation: insights from a bidirectional Mendelian randomization study.

Abstract excerpt

BACKGROUND: Observational studies have suggested that obstructive sleep apnea (OSA) is in relation to atrial fibrillation (AF); however, these studies might be confounded and whether the relationship is causal remains unclear. We conducted a bidirectional Mendelian randomization (MR) study to clarify the causal inference between OSA and AF. METHODS: Genetic instruments for OSA and AF were obtained from...

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• Atrial Fibrillation
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Polymorphism, Single Nucleotide
• Risk Factors