Article
Sleep Disordered Breathing, Obesity and Atrial Fibrillation: A Mendelian Randomisation Study.
Genes - 2 Jan 2022
Ardissino Maddalena, Reddy Rohin K, Slob Eric A W, Patel Kiran H K, Ryan David K, Gill Dipender, Ng Fu Siong
Abstract excerpt
It remains unclear whether the association between obstructive sleep apnoea (OSA), a form of sleep-disordered breathing (SDB), and atrial fibrillation (AF) is causal or mediated by shared co-morbidities such as obesity. Existing observational studies are conflicting and limited by confounding and reverse causality. We performed Mendelian randomisation (MR) to investigate the causal relationships between SDB, body...
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