The effect of weak clonal interference on average fitness trajectories in the presence of macroscopic epistasis.

Abstract excerpt

Adaptation dynamics on fitness landscapes is often studied theoretically in the strong-selection, weak-mutation regime. However, in a large population, multiple beneficial mutants can emerge before any of them fixes in the population. Competition between mutants is known as clonal interference, and while it is known to slow down the rate of adaptation (when compared to the strong-selection, weak-mutation model...

Topics

• Adaptation, Physiological
• Epistasis, Genetic
• Genetic Fitness
• Models, Genetic
• Mutation