Article
Detecting epistasis from an ensemble of adapting populations.
Evolution; international journal of organic evolution - 1 Sept 2015
McCandlish David M, Otwinowski Jakub, Plotkin Joshua B
Abstract excerpt
The role that epistasis plays during adaptation remains an outstanding problem, which has received considerable attention in recent years. Most of the recent empirical studies are based on ensembles of replicate populations that adapt in a fixed, laboratory controlled condition. Researchers often seek to infer the presence and form of epistasis in the fitness landscape from the time evolution of various...
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