Article
The population genetics of adaptation: multiple substitutions on a smooth fitness landscape.
Genetics - 1 Nov 2009
Unckless Robert L, Orr H Allen
Abstract excerpt
Much recent work in the theoretical study of adaptation has focused on the so-called strong selection-weak mutation (SSWM) limit, wherein adaptation is due to new mutations of definite selective advantage. This work, in turn, has focused on the first step (substitution) during adaptive evolution....
Topics
- Adaptation, Physiological
- Algorithms
- Animals
- Evolution, Molecular
- Genetic Fitness
- Genetic Variation
- Genetics, Population
- Humans
- Models, Genetic
- Mutation
- Selection, Genetic