Article
The influence of deleterious mutations on adaptation in asexual populations.
PloS one - 1 Jan 2011
Jiang Xiaoqian, Xu Zhao, Li Jingjing, Shi Youyi, Wu Wenwu, Tao Shiheng
Abstract excerpt
We study the dynamics of adaptation in asexual populations that undergo both beneficial and deleterious mutations. In particular, how the deleterious mutations affect the fixation of beneficial mutations was investigated. Using extensive Monte Carlo simulations, we find that in the "strong-selection weak mutation (SSWM)" regime or in the "clonal interference (CI)" regime, deleterious mutations rarely influence...
Topics
- Adaptation, Physiological
- Evolution, Molecular
- Models, Biological
- Monte Carlo Method
- Mutation
- Reproduction, Asexual
- Selection, Genetic