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Article

Genetic variation in sodium glucose co-transporter 1 and cardiac structure and function at middle age.

ESC heart failure - 1 Apr 2022

Bavishi Aakash, Colangelo Laura A, Rasmussen-Torvik Laura J, Lima Joao A C, Nannini Drew R, Vaduganathan Muthiah, Pandey Ambarish, Lloyd-Jones Donald M, Shah Sanjiv J, Patel Ravi B

Abstract excerpt

AIMS: The effects of inhibition of sodium glucose cotransporter (SGLT)-1, as opposed to SGLT2, on cardiovascular structure and function are not well known. We assessed the associations of a missense genetic variant of SGLT1 with cardiac structure and function. METHODS AND RESULTS: We evaluated associations of a functionally modifying variant of SLC5A1 (rs17683011 [p.Asn51Ser]), the gene that encodes SGLT1, with...

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Identifiers

PMID: 35166069
DOI: 10.1002/ehf2.13841
PMCID: PMC8934939

Genes

GLS
SLC5A1

Variants

rs17683011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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