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Article

The sirtuin1 gene associates with left ventricular myocardial hypertrophy and remodeling in two chronic kidney disease cohorts: a longitudinal study.

Journal of hypertension - 1 Aug 2018

Spoto Belinda, Ntounousi Evangelia, Testa Alessandra, Liakopoulos Vassilios, D'Arrigo Graziella, Tripepi Giovanni, Parlongo Rosa M, Sanguedolce Maria C, Mallamaci Francesca, Zoccali Carmine

Abstract excerpt

BACKGROUND: Oxidative stress and inflammation are major drivers of myocardial hypertrophy in chronic kidney disease (CKD). The silent information regulator gene 1 (Sirt1) is a fundamental mediator of the response to oxidative stress and inflammation and promotes myocardial growth under stress conditions; therefore, it may contribute to myocardial hypertrophy and concentric remodeling of the left ventricle (LV) in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29702498
DOI: 10.1097/HJH.0000000000001746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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