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Article

FBN1: The disease-causing gene for Marfan syndrome and other genetic disorders.

Gene - 10 Oct 2016

Sakai Lynn Y, Keene Douglas R, Renard Marjolijn, De Backer Julie

Abstract excerpt

FBN1 encodes the gene for fibrillin-1, a structural macromolecule that polymerizes into microfibrils. Fibrillin microfibrils are morphologically distinctive fibrils, present in all connective tissues and assembled into tissue-specific architectural frameworks. FBN1 is the causative gene for Marfan syndrome, an inherited disorder of connective tissue whose major features include tall stature and arachnodactyly,...

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Identifiers

PMID: 27437668
DOI: 10.1016/j.gene.2016.07.033
PMCID: PMC6639799

Genes

FBN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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