Article
BMP9 Promotes an Epithelial Phenotype and a Hepatocyte-like Gene Expression Profile in Adult Hepatic Progenitor Cells.
Cells - 21 Jan 2022
Addante Annalisa, González-Corralejo Carlos, Roncero Cesáreo, Lazcanoiturburu Nerea, García-Sáez Juan, Herrera Blanca, Sánchez Aránzazu
Abstract excerpt
Bone morphogenetic protein 9 (BMP9), a member of the TGF-β superfamily, has emerged as a new player in chronic liver diseases (CLDs). Its levels increase in the fibrotic liver where it promotes fibrogenesis. It also regulates hepatic progenitor cells (oval cells in rodents), a cell population that contributes to repopulate the liver and recover functionality upon severe damage, but it can also be pro-fibrogenic,...
Topics
- Growth Differentiation Factor 2
- Hepatocytes
- Liver
- Phenotype
- Stem Cells
- Transcriptome