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Article

Proximity Profiling of the CFTR Interaction Landscape in Response to Orkambi.

International journal of molecular sciences - 23 Feb 2022

Iazzi Melissa, Astori Audrey, St-Germain Jonathan, Raught Brian, Gupta Gagan D

Abstract excerpt

Deletion of phenylalanine 508 (∆F508) of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) anion channel protein is the leading cause of Cystic Fibrosis (CF). Here, we report the analysis of CFTR and ∆F508-CFTR interactomes using BioID (proximity-dependent biotin identification), a technique that can also detect transient associations. We identified 474 high-confidence CFTR proximity-interactors, 57...

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Identifiers

PMID: 35269585
DOI: 10.3390/ijms23052442
PMCID: PMC8910062

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