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Alphavirus antivirals targeting RNA‐dependent RNA polymerase domain of nsP4 divulged using surface plasmon resonance

14 Feb 2022

Abstract excerpt

Alphaviruses are continuously re‐emerging and pose a global threat to human health and currently no antiviral drug is commercially available for alphaviral infections. Alphavirus non‐structural protein nsP4, which possesses RNA‐dependent RNA polymerase (RdRp) activity, is a potential antiviral target. To date, no antiviral drug is commercially available against alphaviruses. Since RdRp is the key virus‐specific...

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PMID: 35156752
DOI: 10.1111/febs.16397

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