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RdRp inhibitors and COVID-19: Is molnupiravir a good option?

8 Dec 2021

Abstract excerpt

Rapid changes in the viral genome allow viruses to evade threats posed by the host immune response or antiviral drugs, and can lead to viral persistence in the host cells. RNA-dependent RNA polymerase (RdRp) is an essential enzyme in RNA viruses, which is involved in RNA synthesis through the formation of phosphodiester bonds. Therefore, in RNA viral infections such as SARS-CoV-2, RdRp could be a crucial...

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PMID: 34902743
DOI: 10.1016/j.biopha.2021.112517

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