Article
Genome-wide association study of brain arteriolosclerosis.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Aug 2022
Shade Lincoln Mp, Katsumata Yuriko, Hohman Timothy J, Nho Kwangsik, Saykin Andrew J, Mukherjee Shubhabrata, Boehme Kevin L, Kauwe John Sk, Farrer Lindsay A, Schellenberg Gerard D, Haines Jonathan L, Mayeux Richard P, Schneider Julie A, Nelson Peter T, Fardo David W
Abstract excerpt
Brain arteriolosclerosis (B-ASC) is characterized by pathologically altered brain parenchymal arterioles. B-ASC is associated with cognitive impairment and increased likelihood of clinical dementia. To date, no study has been conducted on genome-wide genetic risk of autopsy-proven B-ASC. We performed a genome-wide association study (GWAS) of the B-ASC phenotype using multiple independent aged neuropathologic...
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