Article
JAK2V617F mutation status and allele burden in classical Ph-negative myeloproliferative neoplasms in Japan.
International journal of hematology - 1 Jan 2014
Edahiro Yoko, Morishita Soji, Takahashi Kochi, Hironaka Yumi, Yahata Yuriko, Sunami Yoshitaka, Shirane Shuichi, Tsutsui Miyuki, Noguchi Masaaki, Koike Michiaki, Imai Kiyotoshi, Kirito Keita, Noda Naohiro, Sekiguchi Yuji, Tsuneda Satoshi, Ohsaka Akimichi, Araki Marito, Komatsu Norio
Abstract excerpt
JAK2V617F, a gain-of-function mutation in the tyrosine kinase JAK2, is frequently detected in classical myeloproliferative neoplasms (MPNs). In the present study, we determined the JAK2V617F allele burden in Japanese MPN patients using alternately binding probe competitive-polymerase chain reaction, a highly quantitative method recently developed by our group. Although we observed strong similarities in terms of...
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