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Article

Oncogenes, anti-oncogenes and the immune response to cancer: a mathematical model.

Proceedings. Biological sciences - 22 Jun 1992

Sherratt J A, Nowak M A

Abstract excerpt

We develop a mathematical model for the initial growth of a tumour after a mutation in which either an oncogene is expressed or an anti-oncogene (i.e. tumour suppressor gene) is lost. Our model incorporates mitotic control by several biochemicals, with quite different regulatory characteristics, and we consider mutations affecting the cellular response to these control mechanisms. Our mathematical representation...

Topics

Animals
Genes, Tumor Suppressor
Humans
Immunity
Mathematics
Mitosis
Models, Biological
Mutation
Neoplasms
Oncogenes

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1354364
DOI: 10.1098/rspb.1992.0071

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1354364-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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