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Article

Gene- and Gender-Related Decrease in Serum BDNF Levels in Alzheimer's Disease.

International journal of molecular sciences - 23 Nov 2022

Piancatelli Daniela, Aureli Anna, Sebastiani Pierluigi, Colanardi Alessia, Del Beato Tiziana, Del Cane Lorenza, Sucapane Patrizia, Marini Carmine, Di Loreto Silvia

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) has a protective role in Alzheimer's disease (AD). Oxidative stress and inflammatory cytokines are potentially implicated in AD risk. In this study, BDNF was detected in serum of AD and mild cognitive impairment (MCI) patients and investigated in association with gene polymorphisms of BDNF (Val66Met and C270T), of some oxidative stress-related genes (FOXO3A, SIRT3, GLO1,...

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Identifiers

PMID: 36498925
DOI: 10.3390/ijms232314599
PMCID: PMC9740390

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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