Article
Association of host genome with intestinal microbial composition in a large healthy cohort.
Nature genetics - 1 Nov 2016
Turpin Williams, Espin-Garcia Osvaldo, Xu Wei, Silverberg Mark S, Kevans David, Smith Michelle I, Guttman David S, Griffiths Anne, Panaccione Remo, Otley Anthony, Xu Lizhen, Shestopaloff Konstantin, Moreno-Hagelsieb Gabriel, Paterson Andrew D, Croitoru Kenneth
Abstract excerpt
Intestinal microbiota is known to be important in health and disease. Its composition is influenced by both environmental and host factors. Few large-scale studies have evaluated the association between host genetic variation and the composition of microbiota. We recruited a cohort of 1,561 healthy individuals, of whom 270 belong in 123 families, and found that almost one-third of fecal bacterial taxa were...
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