Article
Improvement of a stereoselective biocatalytic synthesis by substrate and enzyme engineering: 2-hydroxy-(4'-oxocyclohexyl)acetonitrile as the model.
Chemistry (Weinheim an der Bergstrasse, Germany) - 1 Jan 2008
Avi Manuela, Wiedner Romana M, Griengl Herfried, Schwab Helmut
Abstract excerpt
Even if biocatalysis is finding increasing application, it still has to gain widespread use in synthetic chemistry. Reasons for this are limitations that enzymes have with regard to substrate range, reaction scope, and insufficient selectivity with unnatural compounds. These shortcomings can be challenged by enzyme and/or substrate engineering, which are employed to alter substrate specificity and enhance the...
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