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Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection

31 Jan 2022

Abstract excerpt

Host cell chromatin changes are thought to play an important role in the pathogenesis of infectious diseases. Here we describe a histone acetylome-wide association study (HAWAS) of an infectious disease, on the basis of genome-wide H3K27 acetylation profiling of peripheral blood granulocytes and monocytes from persons with active Mycobacterium tuberculosis (Mtb) infection and healthy controls. We detected >2,000...

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PMID: 35102304
DOI: 10.1038/s41564-021-01049-w

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