Article
Psycho-cognitive assessment and quality of life in older adults with chronic obstructive pulmonary disease-carrying the rs4713916 gene polymorphism (G/A) of gene FKBP5 and response to pulmonary rehabilitation: a proof of concept study.
Psychiatric genetics - 1 Jun 2022
Marcolongo Federica, Scarlata Simone, Tomino Carlo, De Dominicis Chiara, Giacconi Robertina, Malavolta Marco, Bonassi Stefano, Russo Patrizia, Prinzi Giulia
Abstract excerpt
PURPOSE: Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary and extra-pulmonary multi-morbidity including depression, anxiety and cognitive disorders. Several studies investigated the association of the FKBP5 gene polymorphisms with susceptibility to anxiety, depression, and behavioral disorders. The FKBP5 gene codifies the FKBP51 protein which modulates the glucocorticoid receptor in the...
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