Article
Gene-gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer.
European journal of medical research - 31 Jan 2022
Rosenberger Albert, Muttray Nils, Hung Rayjean J, Christiani David C, Caporaso Neil E, Liu Geoffrey, Bojesen Stig E, Le Marchand Loic, Albanes Demetrios, Aldrich Melinda C, Tardon Adonina, Fernández-Tardón Guillermo, Rennert Gad, Field John K, Davies Michael P A, Liloglou Triantafillos, Kiemeney Lambertus A, Lazarus Philip, Wendel Bernadette, Haugen Aage, Zienolddiny Shanbeh, Lam Stephen, Schabath Matthew B, Andrew Angeline S, Duell Eric J, Arnold Susanne M, Goodman Gary E, Chen Chu, Doherty Jennifer A, Taylor Fiona, Cox Angela, Woll Penella J, Risch Angela, Muley Thomas R, Johansson Mikael, Brennan Paul, Landi Maria Teresa, Shete Sanjay S, Amos Christopher I, Bickeböller Heike
Abstract excerpt
BACKGROUND: Aberrant Wnt signalling, regulating cell development and stemness, influences the development of many cancer types. The Aryl hydrocarbon receptor (AhR) mediates tumorigenesis of environmental pollutants. Complex interaction patterns of genes assigned to AhR/Wnt-signalling were recently associated with lung cancer susceptibility. AIM: To assess the association and predictive ability of AhR/Wnt-genes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.