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Article

Oncogenesis induced by combined Phf6 and Idh2 mutations through increased oncometabolites and impaired DNA repair.

Oncogene - 1 Mar 2022

Chen Tsung-Chih, Yao Chi-Yuan, Chen Yu-Ren, Yuan Chang-Tsu, Lin Chien-Chin, Hsu Yueh-Chwen, Chuang Po-Han, Kao Chein-Jun, Li Yi-Hung, Hou Hsin-An, Chou Wen-Chien, Tien Hwei-Fang

Abstract excerpt

The pathogenesis of acute leukemia involves interaction among genetic alterations. Mutations of IDH1/2 and PHF6 are common and co-exist in some patients of hematopoietic malignancies, but their cooperative effects remain unexplored. In this study, we addressed the question by characterizing the hematopoietic phenotypes of mice harboring neither, Phf6 knockout, Idh2 R172K, or combined mutations. We found that the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Isocitrate Dehydrogenase

Share to Leukemia, Myeloid, Acute

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Identifiers

PMID: 35091680
DOI: 10.1038/s41388-022-02193-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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