Article
Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis.
Translational psychiatry - 26 Jan 2022
Werner Maren Caroline Frogner, Wirgenes Katrine Verena, Shadrin Alexey, Lunding Synve Hoffart, Rødevand Linn, Hjell Gabriela, Ormerod Monica Bettina Elkjær Greenwood, Haram Marit, Agartz Ingrid, Djurovic Srdjan, Melle Ingrid, Aukrust Pål, Ueland Thor, Andreassen Ole Andreas, Steen Nils Eiel
Abstract excerpt
Several lines of evidence implicate immune abnormalities in the pathophysiology of severe mental disorders (SMD) and comorbid mental disorders. Here, we use the data from genome-wide association studies (GWAS) of autoimmune diseases and mental phenotypes associated with SMD to disentangle genetic susceptibilities of immune abnormalities in SMD. We included 1004 patients with SMD and 947 healthy controls (HC) and...
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