Article
Limited association between infections, autoimmune disease and genetic risk and immune activation in severe mental disorders.
Progress in neuro-psychopharmacology & biological psychiatry - 8 Jun 2022
Werner Maren Caroline Frogner, Wirgenes Katrine Verena, Shadrin Alexey A, Lunding Synve Hoffart, Rødevand Linn, Hjell Gabriela, Ormerod Monica Bettina Elkjaer Greenwood, Haram Marit, Agartz Ingrid, Djurovic Srdjan, Melle Ingrid, Aukrust Pål, Ueland Thor, Andreassen Ole Andreas, Steen Nils Eiel
Abstract excerpt
BACKGROUND: Low-grade inflammation may be part of the underlying mechanism of schizophrenia and bipolar disorder. We investigated if genetic susceptibility, infections or autoimmunity could explain the immune activation. METHODS: Seven immune markers were selected based on indicated associations to severe mental disorders (IL-1Ra, sIL-2R, IL-18, sgp130, sTNFR-1, APRIL, ICAM-1) and measured in plasma of patients...
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