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Article

Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis.

Nature medicine - 1 Jan 2022

Korben Vlad A., Lyashchenko Alexander K, Blanco-Redondo Beatriz, Jafar-Nejad Paymaan, Shneider Neil A

Abstract excerpt

Fused in sarcoma (FUS) is an RNA-binding protein that is genetically and pathologically associated with rare and aggressive forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). To explore the mechanisms by which mutant FUS causes neurodegeneration in ALS-FTD, we generated a series of FUS knock-in mouse lines that express the equivalent of ALS-associated mutant FUSP525L and FUSΔEX14...

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Topics

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Share to Amyotrophic Lateral Sclerosis
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Mice, Transgenic

Share to Mutation

Share to Oligonucleotides, Antisense

Share to RNA-Binding Protein FUS

Source

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Identifiers

PMID: 35075293
DOI: 10.1038/s41591-021-01615-z
PMCID: PMC8799464

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis.PMID 35075293Read ↗

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